4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

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Chemical Name:4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide
CAS No.:1278407-36-5
Molecular Formula:C₂₅H₂₄N₆O₂
Molecular Weight:440.505
Hs Code.:

Synonyms:4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

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Chemical Property of 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

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Technology Process of 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

There total 11 articles about 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1278407-70-7
4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid

: 1278407-72-9
6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-ylamine

: 1278407-36-5
4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

Guidance literature:: With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 - 20 ℃;

Reference yield:

: 882499-87-8
methyl 2-amino-5-bromo-pyridine-4-carboxylate

: 1278407-36-5
4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / methanol / 5 h / Reflux

2.1: sodium hydroxide; water / ethanol / 2 h / Reflux

2.2: 0 °C

3.1: triethylamine; diphenyl phosphoryl azide / Reflux; Inert atmosphere

4.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; propylphosphonic anhydride / ethyl acetate / 0 - 20 °C

With potassium phosphate; diphenyl phosphoryl azide; propylphosphonic anhydride; water; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; tricyclohexylphosphine; In methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1278407-60-5
methyl 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylate

: 1278407-36-5
4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 2 h / Reflux

1.2: 0 °C

2.1: triethylamine; diphenyl phosphoryl azide / Reflux; Inert atmosphere

3.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; propylphosphonic anhydride / ethyl acetate / 0 - 20 °C

With potassium phosphate; diphenyl phosphoryl azide; propylphosphonic anhydride; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; tricyclohexylphosphine; In ethanol; dichloromethane; water; ethyl acetate; toluene;