2-Furancarboxaldehyde, phenylhydrazone

Base Information

• Chemical Name: 2-Furancarboxaldehyde, phenylhydrazone
• CAS No.: 2216-75-3
• Molecular Formula: C11H10 N2 O
• Molecular Weight: 186.213
• Hs Code.: 2934999090
• NSC Number: 502
• Nikkaji Number: J95.452G
• Mol file: 2216-75-3.mol

Synonyms:2-Furancarboxaldehyde, phenylhydrazone;AI3-27643;2-Furaldehyde, phenylhydrazone;2216-75-3;Furfuralphenylhydrazone;NSC502;NSC 502;NSC-502

Chemical Property of 2-Furancarboxaldehyde, phenylhydrazone

Chemical Property:

• Vapor Pressure: 0.000884mmHg at 25°C
• Melting Point: 96 °C
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 304.3°Cat760mmHg
• PKA: 14.44±0.10(Predicted)
• Flash Point: 137.8°C
• PSA: 37.53000
• Density: 1.1g/cm³
• LogP: 2.79860
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 188

Purity/Quality:

99.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NN=CC2=CC=CO2
• Isomeric SMILES: C1=CC=C(C=C1)N/N=C\C2=CC=CO2

Technology Process of 2-Furancarboxaldehyde, phenylhydrazone

There total 4 articles about 2-Furancarboxaldehyde, phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

furfural (98-01-1) + phenylhydrazine (100-63-0) → furfural phenylhydrazone (2216-75-3)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.00305556h;

DOI:10.1016/j.molcata.2014.06.024

Reference yield: 94.0%

furfural (98-01-1) + phenylhydrazine hydrochloride (59-88-1) → furfural phenylhydrazone (2216-75-3)

Guidance literature:

With sodium acetate; In ethanol; at 80 ℃; for 0.0833333h; Microwave irradiation; air-cooling;

DOI:10.1021/co100015b

Reference yield:

aniline (62-53-3) → furfural phenylhydrazone (2216-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: sodium acetate / ethanol; water / 20 - 80 °C

With hydrogenchloride; sodium acetate; sodium nitrite; In ethanol; water;

DOI:10.1021/jo2005632

upstream raw materials:

furfural

phenylhydrazine

ethanol

4-furfurylidene-3-phenyl-4H-isoxazol-5-one

Downstream raw materials:

[((CH3)2In)2(OC4H3CHNNC6H5)]2(μ4-O)

N'-phenylfuran-2-carbohydrazonoyl chloride

tert-butyl 4'-tert-butyl-5'-(furan-2-yl)-2-oxo-2'-phenyl-2',4'-dihydrospiro[indoline-3,3'-pyrazole]-1-carboxylate