5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester

Base Information

• Chemical Name: 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester
• CAS No.: 315245-29-5
• Molecular Formula: C₂₆H₂₈O₅Si
• Molecular Weight: 448.591
• Mol file: 315245-29-5.mol

Synonyms:5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester

There total 4 articles about 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid diethyl ester (269411-88-3) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester (315245-29-5)

Guidance literature:

With sodium hydroxide; at 23 ℃; for 72h;

DOI:10.1021/jm9903242

Reference yield: 87.0%

5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid diethyl ester (269411-88-3) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester (315245-29-5)

Guidance literature:

With sodium hydroxide; citric acid; In methanol; at 23 ℃; for 72h;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid monomethyl ester (315245-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 39.9 g / imidazole / dimethylformamide / 23 °C

2: 87 percent / 0.95 N aq. NaOH / 72 h / 23 °C

With 1H-imidazole; sodium hydroxide; In N,N-dimethyl-formamide; 1: silylation / 2: methanolysis;

DOI:10.1021/jm9903242

upstream raw materials:

methanol

5-(tert-butyl-diphenyl-silanyloxymethyl)-isophthalic acid diethyl ester

tert-butylchlorodiphenylsilane

diethyl 5-(hydroxymethyl)isophthalate

Downstream raw materials:

5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

5-(tert-butyl-diphenyl-silanyloxymethyl)-5-formyl-benzoic acid

3-bromomethyl-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

3-((E)-2-Ethoxycarbonyl-vinyl)-5-hydroxymethyl-benzoic acid