2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol

Base Information

• Chemical Name: 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol
• CAS No.: 156214-73-2
• Molecular Formula: C₃₃H₃₃N₅O₂
• Molecular Weight: 531.657
• Mol file: 156214-73-2.mol

Synonyms:2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol

Chemical Property of 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol

There total 7 articles about 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine (102212-26-0) + 2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol (195621-22-8) → 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol (156214-73-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/ja970345q

Reference yield:

2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde (65448-72-8) → 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol (156214-73-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h

2: Et₃N / tetrahydrofuran / Ambient temperature

3: 100 percent / NaBH₄ / methanol / 1.) room temperature, 15 min, 2.) reflux, 30 min

4: 100 percent / SOCl₂ / 3 h / Ambient temperature

5: 45 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja970345q

Reference yield:

3-chloromethyl-5-methylsalicylaldehyde (192819-68-4) → 2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol (156214-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / Ambient temperature

2: 100 percent / NaBH₄ / methanol / 1.) room temperature, 15 min, 2.) reflux, 30 min

3: 100 percent / SOCl₂ / 3 h / Ambient temperature

4: 45 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/ja970345q

upstream raw materials:

N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine

2-(N,N-bis((pyridin-2-yl)methyl)aminomethyl)-6-chloromethyl-4-methylphenol

pyridine-2-carbaldehyde

2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde