ARN-2966

Base Information

• Chemical Name: ARN-2966
• CAS No.: 102212-26-0
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Mol file: 102212-26-0.mol

Synonyms:2-[(Pyridin-2-ylmethyl)-amino]-phenol;ARN2966;N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine;(2-Hydroxyphenyl)(2-pyridylmethyl)amin;2-[(pyridine-2-ylmethyl)-amino]phenol;2-N-(2-pyridylmethyl)aminophenol;

Chemical Property of ARN-2966

Chemical Property:

• Melting Point: 130 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
• Boiling Point: 354.4±27.0 °C(Predicted)
• PKA: 10.22±0.35(Predicted)
• PSA: 45.15000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 2.47230
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

ARN2966(2-PMAP) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ARN-2966

There total 5 articles about ARN-2966 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-[(2-pyridinylmethylene)amino]phenol (3860-58-0) → N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine (102212-26-0)

Guidance literature:

With sodium cyanoborohydride; In methanol; Ambient temperature;

DOI:10.1021/jm00157a020

Reference yield:

(E)-2-((pyridin-2-yl)methyleneamino)phenol → N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine (102212-26-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; Cooling with ice;

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine (102212-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂O / 0.5 h / Ambient temperature

2: 43 percent / sodium cyanoborohydride / methanol / Ambient temperature

With sodium cyanoborohydride; In methanol; water;

DOI:10.1021/jm00157a020

upstream raw materials:

2-[(2-pyridinylmethylene)amino]phenol

pyridine-2-carbaldehyde

2-amino-phenol

Downstream raw materials:

2-(N,N-bis(2-methylpyridyl)aminomethyl)-6-(N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)aminomethyl)-4-methylphenol