p-Methylaminopropiophenone

Base Information

• Chemical Name: p-Methylaminopropiophenone
• CAS No.: 53033-82-2
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• DSSTox Substance ID: DTXSID40201079
• Wikidata: Q83074265
• Mol file: 53033-82-2.mol

Synonyms:p-Methylaminopropiophenone;53033-82-2;Propiophenone, 4'-(N-methylamino)-;BRN 2829461;4-(N-Methylamino)propiophenone;1-Propanone, 1-[4-(methylamino)phenyl]-;SCHEMBL10031656;DTXSID40201079;AKOS022535480

Chemical Property of p-Methylaminopropiophenone

Chemical Property:

• Vapor Pressure: 0.00148mmHg at 25°C
• Boiling Point: 296°C at 760 mmHg
• Flash Point: 126.4°C
• Density: 1.04g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C1=CC=C(C=C1)NC

Technology Process of p-Methylaminopropiophenone

There total 1 articles about p-Methylaminopropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-aminophenyl)-1-propanone (70-69-9) + methyl iodide (74-88-4) → 4-(N-Methylamino)propiophenon (53033-82-2)

Guidance literature:

Multistep reaction; (i) CF₃CO₂H, DCC, iPrOH, CH₂Cl₂, (ii) /BRN= 969135/, acetone;

DOI:10.1021/jm00254a026

Reference yield: 68.0%

formic acid (64-18-6) + 4-(N-Methylamino)propiophenon (53033-82-2) → ethyl p-dimethyaminolbenzoate (10287-53-3)

Guidance literature:

With tris(pentafluorophenyl)borate; In dibutyl ether; at 100 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201503879

Reference yield:

C13H16N4O2S (1393644-03-5) + 4-(N-Methylamino)propiophenon (53033-82-2) → C23H27N5O2S (1393643-56-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water;

DOI:10.1016/j.bmcl.2012.05.130

upstream raw materials:

1-(4-aminophenyl)-1-propanone

methyl iodide

Downstream raw materials:

C₂₃H₂₇N₅O₂S

ethyl p-dimethyaminolbenzoate