diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate
CAS No.:220545-88-0
Molecular Formula:C₃₉H₄₈N₆O₉
Molecular Weight:744.845
Hs Code.:

Synonyms:diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

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Chemical Property of diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

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Technology Process of diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

There total 6 articles about diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 220545-86-8
diethyl N-<4-<4-(5-formyl-4-methoxy-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

: 220545-88-0
diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; for 5h; Ambient temperature;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 220545-88-0
diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Et₃N, 3.) NaBH₄ / 1.) MeOH, room temperature, 1 h, 2.) room temperature, 1 h, 3.) 0 deg C, 1 h

2: 98 percent / Et₃N / ethanol / 6 h / Heating

3: 80 percent / methanol / 3.5 h / Heating

4: 83 percent / DMAP / toluene / 48 h / Heating

5: 78 percent / palladium acetate, PPh₃, CuI, Et₃N / acetonitrile / 36 h / Ambient temperature

6: 97 percent / NH₂OH*HCl, pyridine / ethanol / 5 h / Ambient temperature

With pyridine; dmap; sodium tetrahydroborate; copper(l) iodide; hydroxylamine hydrochloride; palladium diacetate; triethylamine; triphenylphosphine; In methanol; ethanol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 146980-79-2
N-(4-methoxybenzyl)-4-amino-1-butyne

: 220545-88-0
diethyl N-<4-<4-(4-methoxy-5-oximinomethyl-2-pivaloylaminopyrimidin-4-yl)-N-4-methoxybenzylamino>-1-butynyl>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N / ethanol / 6 h / Heating

2: 80 percent / methanol / 3.5 h / Heating

3: 83 percent / DMAP / toluene / 48 h / Heating

4: 78 percent / palladium acetate, PPh₃, CuI, Et₃N / acetonitrile / 36 h / Ambient temperature

5: 97 percent / NH₂OH*HCl, pyridine / ethanol / 5 h / Ambient temperature

With pyridine; dmap; copper(l) iodide; hydroxylamine hydrochloride; palladium diacetate; triethylamine; triphenylphosphine; In methanol; ethanol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(98)01060-6