2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

Base Information

Chemical Name:2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine
CAS No.:220545-81-3
Molecular Formula:C₁₈H₂₀N₄O₃
Molecular Weight:340.382
Hs Code.:

Synonyms:2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

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Chemical Property of 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

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Technology Process of 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

There total 3 articles about 2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124-41-4
sodium methylate

: 220545-79-9
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-4-chloro-5-formylpyrimidine

: 220545-81-3
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

Guidance literature:: In methanol; for 3.5h; Heating;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 220545-81-3
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, 3.) NaBH₄ / 1.) MeOH, room temperature, 1 h, 2.) room temperature, 1 h, 3.) 0 deg C, 1 h

2: 98 percent / Et₃N / ethanol / 6 h / Heating

3: 80 percent / methanol / 3.5 h / Heating

With sodium tetrahydroborate; triethylamine; In methanol; ethanol;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 146980-79-2
N-(4-methoxybenzyl)-4-amino-1-butyne

: 220545-81-3
2-amino-6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxypyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / Et₃N / ethanol / 6 h / Heating

2: 80 percent / methanol / 3.5 h / Heating

With triethylamine; In methanol; ethanol;
DOI:10.1016/S0040-4020(98)01060-6