(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Base Information

Chemical Name:(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one
CAS No.:575444-18-7
Molecular Formula:C₃₂H₄₁NO₄Si
Molecular Weight:531.767
Hs Code.:

Synonyms:(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Suppliers and Price of (3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

There total 13 articles about (3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 575444-17-6
(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-5,6-diphenyl-morpholin-2-one

: 575444-18-7
(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Guidance literature:: With sodium cyanoborohydride; In acetonitrile;
DOI:10.1016/S0040-4039(03)01082-7

Reference yield:

: 82628-68-0
3,4-dihydroxy-5-methylbenzaldehyde

: 575444-18-7
(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 82 percent / Et₃N / dimethylformamide

2: 88 percent / K₂CO₃ / acetone

3: 82 percent / TBAF / tetrahydrofuran

4: 86 percent / K₂CO₃ / acetone

5: 100 percent / LiAlH₄ / diethyl ether

6: 94 percent / CBr₄; Ph₃P / tetrahydrofuran

7: NaHDMS / tetrahydrofuran / -78 °C

8: 95 percent / hydrrogen / Pd/C / ethanol / 760 Torr

9: 82 percent / DMAP; Et₃N / CH₂Cl₂

10: 93 percent / TFA / CH₂Cl₂

11: 77 percent / NaBH₃CN / acetonitrile

With dmap; lithium aluminium tetrahydride; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; sodium cyanoborohydride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/S0040-4039(03)01082-7

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 575444-18-7
(3S,5S,6R)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-4-methyl-5,6-diphenyl-morpholin-2-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: Me₂NH / ethanol

1.2: conc. HCl; SnCl₂

1.3: AlCl₃; pyridine / CH₂Cl₂

2.1: 82 percent / Et₃N / dimethylformamide

3.1: 88 percent / K₂CO₃ / acetone

4.1: 82 percent / TBAF / tetrahydrofuran

5.1: 86 percent / K₂CO₃ / acetone

6.1: 100 percent / LiAlH₄ / diethyl ether

7.1: 94 percent / CBr₄; Ph₃P / tetrahydrofuran

8.1: NaHDMS / tetrahydrofuran / -78 °C

9.1: 95 percent / hydrrogen / Pd/C / ethanol / 760 Torr

10.1: 82 percent / DMAP; Et₃N / CH₂Cl₂

11.1: 93 percent / TFA / CH₂Cl₂

12.1: 77 percent / NaBH₃CN / acetonitrile

With dmap; lithium aluminium tetrahydride; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; sodium cyanoborohydride; potassium carbonate; dimethyl amine; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/S0040-4039(03)01082-7