4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

Base Information

Chemical Name:4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol
CAS No.:1417620-28-0
Molecular Formula:C₁₄H₁₂ClN₃O₂S
Molecular Weight:321.787
Hs Code.:

Synonyms:4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

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Chemical Property of 4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

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Technology Process of 4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

There total 5 articles about 4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1417620-27-9
7-chloro-2-(4-methoxy-3,5-dimethylphenyl)-5-methylsulfanyloxazolo[5,4-d]pyrimidine

: 1417620-28-0
4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

Guidance literature:: 7-chloro-2-(4-methoxy-3,5-dimethylphenyl)-5-methylsulfanyloxazolo[5,4-d]pyrimidine; With boron tribromide; In dichloromethane; at -20 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water; at -20 ℃;

Reference yield:

: 21668-34-8
3,5-dimethyl-4-methoxybenzoic acid chloride

: 1417620-28-0
4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: sodium methylate / ethanol; methanol / 0.25 h

2.2: 3 h / 60 °C

3.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

3.2: 2 h / 0 °C

3.3: pH 2

4.1: trichlorophosphate / 36 h / 70 °C

5.1: boron tribromide / dichloromethane / 4 h / -20 - 20 °C

5.2: -20 °C

With sodium methylate; boron tribromide; triethylamine; sodium hydroxide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1315456-71-3
sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate

: 1417620-28-0
4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

1.2: 2 h / 0 °C

1.3: pH 2

2.1: trichlorophosphate / 36 h / 70 °C

3.1: boron tribromide / dichloromethane / 4 h / -20 - 20 °C

3.2: -20 °C

With boron tribromide; sodium hydroxide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water;