(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

Base Information

Chemical Name:(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine
CAS No.:898529-76-5
Molecular Formula:C₁₉H₂₁N₃O
Molecular Weight:307.395
Hs Code.:

Synonyms:(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

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Technology Process of (+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

There total 4 articles about (+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 100-39-0
benzyl bromide

: 81335-74-2
(+/-)-2-(4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

: 898529-76-5
(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1016/j.jorganchem.2006.01.056

Reference yield:

: 898529-74-3
(+/-)-2-{[2-(aminocarbonyl)-3-methylbut-2-yl]aminocarbonyl}pyridine

: 898529-76-5
(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaOH / H₂O / 5 h / 20 °C

2: 65 percent / Cs₂CO₃ / dimethylformamide / 24 h / 90 °C

With sodium hydroxide; caesium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2006.01.056

Reference yield:

: 98-98-6
2-Picolinic acid

: 898529-76-5
(+/-)-2-(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one-2-yl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; ethyl chloroformate / tetrahydrofuran / 0.5 h

1.2: 78 percent / tetrahydrofuran / 3 h

2.1: 76 percent / NaOH / H₂O / 5 h / 20 °C

3.1: 65 percent / Cs₂CO₃ / dimethylformamide / 24 h / 90 °C

With sodium hydroxide; chloroformic acid ethyl ester; caesium carbonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2006.01.056