7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Base Information

• Chemical Name: 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
• CAS No.: 808186-26-7
• Molecular Formula: C₁₂H₁₁F₂NO₂
• Molecular Weight: 239.222
• Mol file: 808186-26-7.mol

Synonyms:7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Chemical Property of 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

There total 3 articles about 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanolamine (141-43-5) + 4-(2,4-difluorophenyl)-4-oxobutanoic acid (110931-77-6) → 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one (808186-26-7)

Guidance literature:

In toluene; for 16h; Heating;

DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

1,3-Difluorobenzene (372-18-9) → 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one (808186-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / aluminum chloride / 0 - 80 °C

2: 90 percent / aq. LiOH / tetrahydrofuran

3: 100 percent / toluene / 16 h / Heating

With lithium hydroxide; aluminium trichloride; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

4-(2,4-difluoro-phenyl)-4-oxo-butyryl chloride → 7a-(2,4-difluoro-phenyl)-tetrahydro-pyrrolo[2,1-b]oxazol-5-one (808186-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. LiOH / tetrahydrofuran

2: 100 percent / toluene / 16 h / Heating

With lithium hydroxide; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2004.09.001

upstream raw materials:

ethanolamine

4-(2,4-difluorophenyl)-4-oxobutanoic acid

1,3-Difluorobenzene

Downstream raw materials:

5-(2,4-difluoro-phenyl)-1-(2-hydroxy-ethyl)-pyrrolidin-2-one

1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-pyrrolidin-2-one