N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

Base Information

Chemical Name:N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine
CAS No.:1204331-80-5
Molecular Formula:C₁₉H₂₅F₃N₄O₃
Molecular Weight:414.428
Hs Code.:

Synonyms:N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

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Chemical Property of N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

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Technology Process of N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

There total 20 articles about N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1204331-79-2
4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

: 1204331-80-5
N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

Guidance literature:: With hydrogen; palladium hydroxide, 20 wt% on carbon; In ethanol; for 16h; Inert atmosphere;

Reference yield: 82.0%

: 1204331-79-2
4-(4-(N-tert-butoxycarbonyl)guanidinocarbonyl-2-trifluoromethyl-phenyl)piperidine-1-carboxylic acid benzyl ester

: 1204331-80-5
N-(4-piperidin-4-yl-3-trifluoromethylbenzoyl)-N'-(tert-butoxycarbonyl)guanidine

Guidance literature:: With Pd(OH)2/C; hydrogen; In ethanol; for 36h;
DOI:10.1021/jm300601d

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1204331-80-5
N-(4-piperidin-4-yl-3-trifluoromethyl-benzoyl)-(N'-tert-butoxycarbonyl)-guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

2.1: hydrogen; acetic acid / platinum(IV) oxide / 60 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: water; potassium carbonate / methanol / 16 h / 20 °C

6.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

6.2: 2 h

7.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 16 h / Inert atmosphere

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide, 20 wt% on carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; 1.1: Suzuki Coupling;