4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

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Chemical Name:4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester
CAS No.:1204331-79-2
Molecular Formula:C₂₇H₃₁F₃N₄O₅
Molecular Weight:548.562
Hs Code.:

Synonyms:4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of 4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

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Technology Process of 4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

There total 15 articles about 4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1204331-78-1
4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

: 219511-71-4
tert-butyl N-(diaminomethylidene)carbamate

: 1204331-79-2
4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: 4-(4-carboxy-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester; With 2-chloro-1-methyl-pyridinium iodide; In 1-methyl-pyrrolidin-2-one; for 1.5h;

tert-butyl N-(diaminomethylidene)carbamate; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; for 2h;

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1204331-79-2
4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 80 °C / Sealed tube

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

3.1: hydrogen; acetic acid / platinum(IV) oxide / 60 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 50 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: water; potassium carbonate / methanol / 16 h / 20 °C

7.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

7.2: 2 h

With hydrogenchloride; sulfuric acid; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1204331-79-2
4-(4-(N-(tert-butoxycarbonyl)-guanidinocarbonyl)-2-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

2.1: hydrogen; acetic acid / platinum(IV) oxide / 60 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: water; potassium carbonate / methanol / 16 h / 20 °C

6.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

6.2: 2 h

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; 1.1: Suzuki Coupling;