N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine

Base Information

• Chemical Name: N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine
• CAS No.: 320337-22-2
• Molecular Formula: C₂₅H₂₁ClFN₃O₂
• Molecular Weight: 449.912

Synonyms:N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine

Chemical Property of N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine

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Technology Process of N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine

There total 7 articles about N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tributyl(1-ethoxyvinyl)stannane (97674-02-7) + N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine (231278-20-9) → N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine (320337-22-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; for 18h; Reflux;

Reference yield:

4-chloro-6-iodoquinazoline (98556-31-1) → N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine (320337-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol

2: Pd(PPh₃)2Cl₂

With bis-triphenylphosphine-palladium(II) chloride; In isopropyl alcohol;

DOI:10.1016/S0960-894X(02)01047-8

Reference yield:

3-chloro-4-(3-fluorobenzyloxy)aniline (202197-26-0) → N-((4-(3-fluorobenzyloxy)-chlorophenyl)-6-(1-ethoxyethenyl)-quinazolin-4-yl)-amine (320337-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol

2: Pd(PPh₃)2Cl₂

With bis-triphenylphosphine-palladium(II) chloride; In isopropyl alcohol;

DOI:10.1016/S0960-894X(02)01047-8

upstream raw materials:

tributyl(1-ethoxyvinyl)stannane

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

4-chloro-6-iodoquinazoline

3-chloro-4-(3-fluorobenzyloxy)aniline

Downstream raw materials:

N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-(6-(2-bromoethanone)-quinazolin-4-yl)-amine

(4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine

N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine

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