(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1199828-87-9
Molecular Formula:C₂₅H₂₄F₃N₃O₄
Molecular Weight:487.478
Hs Code.:

Synonyms:(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 6 articles about (S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1251457-90-5
C₁₈H₁₈ClNO₂

: 155377-19-8
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1199828-87-9
(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield:

: 889362-93-0
(S)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-ylcarbamate

: 1199828-87-9
(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave

2: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen

3: thionyl chloride / dichloromethane / 0.75 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With lithium borohydride; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1199828-07-3
(S)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate

: 1199828-87-9
(S)-ethyl 1-((2-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0.75 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;