Technology Process of (S)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate
There total 4 articles about (S)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-methyl 2-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-5-carboxylate;
With
lithium borohydride;
In
tetrahydrofuran; methanol;
at 20 ℃;
Inert atmosphere of nitrogen;
With
water;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave
2: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen
With
lithium borohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine / water / 1.67 h / 58 - 60 °C / Inert atmosphere of N2
1.2: 20 - 60 °C
2.1: 4-methyl-morpholine / methanol / 4 h / 20 - 65 °C
3.1: potassium carbonate / water; ethyl acetate / 20 °C / Cooling with ice bath
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave
5.1: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen
With
4-methyl-morpholine; lithium borohydride; bromine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl;
In
tetrahydrofuran; methanol; water; ethyl acetate;
