3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

Base Information

Chemical Name:3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol
CAS No.:1301664-22-1
Molecular Formula:C₂₄H₂₇NO₄S
Molecular Weight:425.549
Hs Code.:

Synonyms:3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

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Chemical Property of 3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

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Technology Process of 3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

There total 7 articles about 3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1301664-12-9
N-ethynyl-5-methyl-N(-p-tosyl)hexa-3,4-dien-1-amine

: 123-11-5
4-methoxy-benzaldehyde

: 1301664-22-1
3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 13h; Inert atmosphere;
DOI:10.1021/ol201041h

Reference yield:

: 1301664-11-8
5-methyl-N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)hexa-3,4-dien-1-amine

: 1301664-22-1
3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 25 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;
DOI:10.1021/ol201041h

Reference yield:

: 54795-27-6
5-methyl-3,4-hexadien-1-ol

: 1301664-22-1
3-(N-(5-methylhexa-3,4-dienyl)-N-(p-tosyl)amino)-1-(4-methoxyphenyl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

3: iron(III) chloride hexahydrate; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 16 h / 90 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

5: n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 25 °C / Inert atmosphere

With n-butyllithium; iron(III) chloride hexahydrate; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1021/ol201041h