(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Base Information

Chemical Name:(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine
CAS No.:156365-84-3
Molecular Formula:C₁₈H₂₆N₂O₅
Molecular Weight:350.415
Hs Code.:

Synonyms:(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Suppliers and Price of (2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Technology Process of (2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

There total 5 articles about (2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 156365-82-1
(2S,4S,5R)-2-ethoxycarbonyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

: 156365-84-3
(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: With triethylaluminum; In hexane; dichloromethane; -20 deg C to room temp.; room temp., 1 h; -30 deg C to room temp.; room temp., 3 h;
DOI:10.1016/0040-4020(95)00145-X

Reference yield: 70.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 156365-83-2
(2S,4S,5R)-2-carboxy-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

: 156365-84-3
(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: With dicyclohexyl-carbodiimide; In pyridine;
DOI:10.1016/S0040-4039(00)76893-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 156365-84-3
(2S,4S,5R)-2-(N-methoxy-N-methyl)-carbamoyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) toluene, reflux; 2.) AcOEt, 50 deg C, rapid addition

2: 90 percent / LiOH

3: 70 percent / DCC / pyridine

With lithium hydroxide; dicyclohexyl-carbodiimide; In pyridine;
DOI:10.1016/S0040-4039(00)76893-6