(R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate
• CAS No.: 1339950-10-5
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.417
• Mol file: 1339950-10-5.mol

Synonyms:(R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property of (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 1 articles about (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzyl bromide (100-39-0) + 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (108149-63-9) → (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1339950-10-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 12h; Cooling with ice;

DOI:10.1055/s-0030-1260120

Reference yield: 86.0%

(R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1339950-10-5) → tert-butyl N-[(1S)-1-(benzyloxymethyl)-2-hydroxy-ethyl]carbamate (79069-15-1)

Guidance literature:

With hydrogenchloride; water; In methanol; at 20 ℃; Cooling with ice;

DOI:10.1055/s-0030-1260120

Reference yield:

(R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1339950-10-5) → tert-butyl (R)-(1-(benzyloxy)-3-oxopropan-2-yl)carbamate (350685-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 20 °C / Cooling with ice

2: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - -35 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; water; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 2: Swern oxidation;

DOI:10.1055/s-0030-1260120

upstream raw materials:

benzyl bromide

4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

C₁₇H₂₅NO₄

C₁₇H₂₅NO₄

tert-butyl N-[(1S)-1-(benzyloxymethyl)-2-hydroxy-ethyl]carbamate

tert-butyl (R)-(1-(benzyloxy)-3-oxopropan-2-yl)carbamate