TYRPHOSTIN AG 1290

Base Information

Chemical Name:TYRPHOSTIN AG 1290
CAS No.:160391-70-8
Molecular Formula:C₁₀H₆N₂O₆
Molecular Weight:250.167
Hs Code.:
Mol file:160391-70-8.mol

Synonyms:(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

Suppliers and Price of TYRPHOSTIN AG 1290

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EntacaponeAcid
1g
$ 120.00

American Custom Chemicals Corporation
TYRPHOSTIN AG 1290 95.00%
5MG
$ 505.91

Total 8 raw suppliers

Chemical Property of TYRPHOSTIN AG 1290

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

EntacaponeAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Entacapone Acid, is the acid derivative of Entacapone (E558500). (E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.

Technology Process of TYRPHOSTIN AG 1290

There total 1 articles about TYRPHOSTIN AG 1290 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.05%

: 116313-85-0
3,4-dihydroxy-5-nitrobenzaldehyde

: 372-09-8
cyanoacetic acid

: 160391-70-8
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

Guidance literature:: With piperidine; pyridine; at 60 ℃; for 24h;
DOI:10.1021/acs.jmedchem.6b00666

Reference yield: 100.0%

: 160391-70-8
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

: 1291066-63-1
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; Heating;

Reference yield: 45.04%

: 160391-70-8
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

: 100-39-0
benzyl bromide

: benzyl (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylate

Guidance literature:: (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid; With potassium phosphate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

benzyl bromide; In dimethyl sulfoxide; at 20 ℃; for 24h;
DOI:10.1021/acs.jmedchem.6b00666