Entacapone EP Impurity G

Base Information

Chemical Name:Entacapone EP Impurity G
CAS No.:1364322-41-7
Molecular Formula:C₁₁H₉N₃O₅
Molecular Weight:263.21
Hs Code.:
Mol file:1364322-41-7.mol

Synonyms:

Suppliers and Price of Entacapone EP Impurity G

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N-Bis-desethyl,N-MethylEntacapone
2.5g
$ 1320.00

Total 8 raw suppliers

Chemical Property of Entacapone EP Impurity G

Chemical Property:

Boiling Point:544.6±50.0 °C(Predicted)
PKA:4.88±0.50(Predicted)
Density:1.537±0.06 g/cm3(Predicted)

Purity/Quality:

> 95% ^*data from raw suppliers

N,N-Bis-desethyl,N-MethylEntacapone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N,N-Bis-desethyl, N-Methyl Entacapone is an impurity of Entacapone (E558500). The (E)-Isomer of Entacapone which is a polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.

Technology Process of Entacapone EP Impurity G

There total 3 articles about Entacapone EP Impurity G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116313-85-0
3,4-dihydroxy-5-nitrobenzaldehyde

: 1364322-41-7
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N-methylprop-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; acetic acid / ethanol / 4 h / 80 °C

2: thionyl chloride / 25 - 80 °C

3: 0 °C

With piperidine; thionyl chloride; acetic acid; In ethanol; 1: Knoevenagel condensation;
DOI:10.1080/00397911.2010.539894

Reference yield:

: 160391-70-8
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

: 1364322-41-7
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N-methylprop-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 25 - 80 °C

2: 0 °C

With thionyl chloride;
DOI:10.1080/00397911.2010.539894