4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

Base Information

Chemical Name:4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide
CAS No.:1346665-31-3
Molecular Formula:C₁₈H₁₂ClF₃N₄O₃
Molecular Weight:424.766
Hs Code.:

Synonyms:4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

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Chemical Property of 4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

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Technology Process of 4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

There total 4 articles about 4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 344591-91-9
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid

: 1346665-30-2
C₁₃H₈BrClN₂O₃

: 1346665-31-3
4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1346665-31-3
4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 3 h / 80 °C / Inert atmosphere

With dmap; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 1346665-31-3
4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 3 h / 80 °C / Inert atmosphere

With dmap; oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;