4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

Base Information

Chemical Name:4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine
CAS No.:1590460-03-9
Molecular Formula:C₂₀H₁₆ClN₃O
Molecular Weight:349.82
Hs Code.:

Synonyms:4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

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Technology Process of 4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

There total 6 articles about 4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1590460-02-8
4-chloro-5-iodo-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 5720-07-0
4-methoxyphenylboronic acid

: 1590460-03-9
4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1002/ejoc.201301496

Reference yield: 33.0%

: 1590460-01-7
5-bromo-4-chloro-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 5720-07-0
4-methoxyphenylboronic acid

: 1590460-03-9
4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1002/ejoc.201301496

Reference yield:

: 1590459-85-0
4-chloro-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 1590460-03-9
4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; sodium carbonate; In 1,2-dimethoxyethane; water; acetonitrile; 2: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201301496