5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

Base Information

Chemical Name:5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine
CAS No.:1590460-09-5
Molecular Formula:C₂₇H₂₃N₃O
Molecular Weight:405.499
Hs Code.:

Synonyms:5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

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Chemical Property of 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

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Technology Process of 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

There total 9 articles about 5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1590460-03-9
4-chloro-5-(4-methoxyphenyl)-7-methyl-6-phenyl-7H-pyrrolo[2,3-d]-pyrimidine

: 5720-05-8
4-methylphenylboronic acid

: 1590460-09-5
5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; Microwave irradiation;
DOI:10.1002/ejoc.201301496

Reference yield: 65.0%

: 1590459-96-3
5-iodo-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo[2,3-d]pyrimidine

: 5720-07-0
4-methoxyphenylboronic acid

: 1590460-09-5
5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; chemoselective reaction; Microwave irradiation; Inert atmosphere;
DOI:10.1002/ejoc.201301496

Reference yield:

: 65766-32-7
6-chloro-N-methylpyrimidin-4-amine

: 1590460-09-5
5-(4-methoxyphenyl)-7-methyl-6-phenyl-4-(4-tolyl)-7H-pyrrolo-[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

2: bis(dibenzylideneacetone)-palladium⁽⁰⁾; trifuran-2-yl-phosphane; copper(l) iodide; triethylamine / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

3: caesium carbonate / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

4: N-Bromosuccinimide / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

5: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; caesium carbonate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; 2: |Sonogashira Cross-Coupling / 5: |Suzuki-Miyaura Coupling / 6: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201301496