6-chloro-Nmethylpyrimidin-4-amine

Base Information

• Chemical Name: 6-chloro-Nmethylpyrimidin-4-amine
• CAS No.: 65766-32-7
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.576
• Hs Code.: 2933599090
• Mol file: 65766-32-7.mol

Synonyms:(6-Chloropyrimidin-4-yl)methylamine;6-Chloro-4-(methylamino)pyrimidine;NSC 211762;6-Chloro-N-methyl-4-pyrimidinamine;

Chemical Property of 6-chloro-Nmethylpyrimidin-4-amine

Chemical Property:

• Melting Point: 138-142°C
• Boiling Point: 279.7 °C at 760 mmHg
• PKA: 2.50±0.10(Predicted)
• Flash Point: 122.9 °C
• PSA: 37.81000
• Density: 1.338 g/cm³
• LogP: 1.24470
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6-methylaminopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-chloro-Nmethylpyrimidin-4-amine

There total 4 articles about 6-chloro-Nmethylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.43%

4,6-dichloropyrimidine (1193-21-1) + methylamine (74-89-5) → 6-chloro-N-methylpyrimidin-4-amine (65766-32-7)

Guidance literature:

In tetrahydrofuran; isopropyl alcohol; at 0 - 20 ℃;

Reference yield: 78.0%

4,6-dichloropyrimidine (1193-21-1) + methylamine hydrochloride (593-51-1) → 6-chloro-N-methylpyrimidin-4-amine (65766-32-7)

Guidance literature:

With triethylamine; In isopropyl alcohol; Microwave irradiation; Reflux;

DOI:10.1002/ejoc.201301496

Reference yield:

(2,6-dichloro-pyrimidin-4-yl)-methyl-amine (32998-03-1) → 6-chloro-N-methylpyrimidin-4-amine (65766-32-7)

Guidance literature:

With phosphorus; hydrogen iodide;

upstream raw materials:

4,6-dichloropyrimidine

methylamine

(2,6-dichloro-pyrimidin-4-yl)-methyl-amine

methylamine hydrochloride

Downstream raw materials:

6-methoxy-N-methylpyrimidin-4-amine

[4-(6-methylamino-pyrimidin-4-ylamino)-phenyl]-arsonic acid ; hydrochloride

6-(methylamino)pyrimidin-4(3H)-one

5-amino-6-(methylamino)pyrimidin-4(3H)-one