<1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Base Information

• Chemical Name: <1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide
• CAS No.: 132178-72-4
• Molecular Formula: C₂₆H₃₄N₂O₆
• Molecular Weight: 470.566

Synonyms:<1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Chemical Property of <1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of <1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

There total 2 articles about <1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester (127696-10-0) → <1S-<1α(S*),2β(S*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132178-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 2 N KOH / methanol / 1 h / 43 °C

2: DCC / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00108a026

Reference yield:

D-2-phenylglycinol (56613-80-0) + trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid (132178-71-3) → <1S-<1α(S*),2β(S*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132178-72-4) + <1R-<1α(R*),2β(R*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132294-21-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm00108a026

Reference yield:

<1S-<1α(S*),2β(S*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132178-72-4) + tert-butyldimethylsilyl chloride (18162-48-6) → [1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide (132178-73-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 5 ℃; for 1.5h;

DOI:10.1021/jm00108a026

upstream raw materials:

D-2-phenylglycinol

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester

Downstream raw materials:

[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

C₃₈H₆₀N₄O₈Si₂

(1S-trans)-3,3-diethoxy-1,2-cyclobutanedimethanol

<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

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