6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Base Information

• Chemical Name: 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine
• CAS No.: 149981-38-4
• Molecular Formula: C₁₃H₁₄N₄O₃
• Molecular Weight: 274.279
• Mol file: 149981-38-4.mol

Synonyms:6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Chemical Property of 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine

There total 3 articles about 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

benzoyl chloride (98-88-4) + 6-amino-1-methyl-5-(methylamino)pyrimidine-2,4-dione (55441-70-8) → 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine (149981-38-4)

Guidance literature:

With pyridine; at 0 ℃;

DOI:10.1021/jm970515+

Reference yield:

6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (14094-37-2) → 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine (149981-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 4 h / 70 °C

2: 73 percent / pyridine / methanol / 12 h / 20 °C

With pyridine; In methanol; water;

DOI:10.1021/jm011093d

Reference yield:

6-amino-1-methyluracil (2434-53-9) → 6-amino-1-methyl-5-methyl(phenyl)carboxamido-2,3-dioxo-1,2,3,4-tetrahydropyrimidine (149981-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂; NaHCO₃ / methanol / 0.5 h / 20 °C

2: H₂O / 4 h / 70 °C

3: 73 percent / pyridine / methanol / 12 h / 20 °C

With pyridine; bromine; sodium hydrogencarbonate; In methanol; water;

DOI:10.1021/jm011093d

upstream raw materials:

benzoyl chloride

6-amino-1-methyl-5-(methylamino)pyrimidine-2,4-dione

6-amino-1-methyluracil

6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

1,3,7-trimethyl-8-phenylxanthine

6-((S)-1-Hydroxymethyl-propylamino)-3,7-dimethyl-8-phenyl-3,7-dihydro-purin-2-one

6-((R)-1-Hydroxymethyl-propylamino)-3,7-dimethyl-8-phenyl-3,7-dihydro-purin-2-one

6-(1-hydroxymethyl-propylamino)-3,7-dimethyl-8-phenyl-3,7-dihydro-purin-2-one