(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester
CAS No.:156706-57-9
Molecular Formula:C₂₆H₄₁Cl₃N₂O₆Si
Molecular Weight:612.066
Hs Code.:

(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

Synonyms:(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of (S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

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Technology Process of (S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

There total 5 articles about (S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 119706-71-7
N-(tert-butoxycarbonyl)-O-[tert-butyl(dimethyl)silyl]-N-methyl-D-tyrosine

: H-Ala-OTce*HCl

: 156706-57-9
(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1016/S0040-4039(00)75846-1

Reference yield:

: 119706-75-1
(R)-2-(tert-butoxycarbonylamino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid

: 156706-57-9
(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 1,7 M Bu^tLi in pentane / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C to RT, 7.5 h

2: 79 percent / diethyl phosphonocyanide, Et₃N / dimethylformamide / 0 deg C, 30 min; RT, 16 h

With diethyl cyanophosphonate; tert.-butyl lithium; triethylamine; In N,N-dimethyl-formamide;
DOI:10.3987/COM-97-S41

Reference yield:

: 86555-51-3
t-BOC-L-Alanine 2,2,2-Trichloroethyl Ester

: 156706-57-9
(S)-2-{(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 4N HCl in dioxane / 0 deg C, 10 min; RT, 2 h

2: 79 percent / diethyl phosphonocyanide, Et₃N / dimethylformamide / 0 deg C, 30 min; RT, 16 h

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.3987/COM-97-S41