(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester
CAS No.:201666-89-9
Molecular Formula:C₂₂H₃₃N₅O₆
Molecular Weight:463.534
Hs Code.:

Synonyms:(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

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Chemical Property of (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

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Technology Process of (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

There total 3 articles about (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 201666-99-1
(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

: 201666-89-9
(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: With diethylamine; In acetonitrile; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/ol802817t

Reference yield:

: 160885-44-9
(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

: 201666-89-9
(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, HOBT hydrate / tetrahydrofuran / 0 - 25 °C

2: Et₂NH / acetonitrile

With benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;
DOI:10.1039/a706206k

Reference yield:

: 160885-43-8
(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

: 201666-89-9
(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TFA, PhOH / CH₂Cl₂ / 25 °C

2: DCC, HOBT hydrate / tetrahydrofuran / 0 - 25 °C

3: Et₂NH / acetonitrile

With benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; phenol; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/a706206k