(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

Base Information

• Chemical Name: (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester
• CAS No.: 160885-44-9
• Molecular Formula: C₃₂H₃₃N₃O₇
• Molecular Weight: 571.63
• Mol file: 160885-44-9.mol

Synonyms:(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

Chemical Property of (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

There total 5 articles about (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-43-8) → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester (160885-44-9)

Guidance literature:

With trifluoroacetic acid; phenol; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

Fmoc-D-MeAla-Cl (144073-16-5) → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester (160885-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: AgCN / toluene / 1 h / 70 °C

2: 97 percent / TFA, PhOH / CH₂Cl₂ / Ambient temperature

With silver cyanide; trifluoroacetic acid; phenol; In dichloromethane; toluene;

DOI:10.1016/S0040-4039(00)78375-4

Reference yield:

(2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino}propanoic acid → (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester (160885-44-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2 / CH₂Cl₂ / 2 h / 25 °C

2: AgCN / toluene / 1 h / 70 °C

3: 97 percent / TFA, PhOH / CH₂Cl₂ / Ambient temperature

With silver cyanide; oxalyl dichloride; trifluoroacetic acid; phenol; In dichloromethane; toluene;

DOI:10.1016/S0040-4039(00)78375-4

upstream raw materials:

(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Fmoc-D-MeAla-Cl

(S)-Tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

(3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester

Downstream raw materials:

C₆₆H₈₁N₇O₁₄Si

C₅₁H₇₁N₇O₁₂Si

(S)-3-[(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

C₆₈H₆₈N₆O₁₂