(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester
• CAS No.: 201666-99-1
• Molecular Formula: C₃₇H₄₃N₅O₈
• Molecular Weight: 685.777
• Mol file: 201666-99-1.mol

Synonyms:(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Chemical Property of (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

There total 3 articles about (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) + (S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester (160885-44-9) → (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester (201666-99-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 25 ℃; Yield given;

DOI:10.1039/a706206k

Reference yield:

Fmoc-D-MeAla-Cl (144073-16-5) + (3S)-N(1)-Z-piperazic acid t-butylhydrazide (439292-93-0) → (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester (201666-99-1)

Guidance literature:

With silver cyanide; In benzene; at 80 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/ol802817t

Reference yield:

(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester (160885-43-8) → (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester (201666-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA, PhOH / CH₂Cl₂ / 25 °C

2: DCC, HOBT hydrate / tetrahydrofuran / 0 - 25 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; phenol; In tetrahydrofuran; dichloromethane;

DOI:10.1039/a706206k

upstream raw materials:

t-butoxycarbonylhydrazine

(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester

(S)-2-{(R)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Fmoc-D-MeAla-Cl

Downstream raw materials:

(S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-((R)-2-methylamino-propionyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

C₆₈H₆₈N₆O₁₂

C₆₀H₆₈N₈O₁₃

(S)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester