N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Base Information

Chemical Name:N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide
CAS No.:1195768-25-2
Molecular Formula:C₁₈H₁₁ClF₃N₃O₃S
Molecular Weight:441.818
Hs Code.:

Synonyms:N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Suppliers and Price of N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

There total 10 articles about N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 13036-57-2
2-chloro-4-methylpyrimidine

: 1195768-24-1
3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

: 1195768-25-2
N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Guidance literature:: 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃; for 0.333333h; Inert atmosphere;

2-chloro-4-methylpyrimidine; In tetrahydrofuran; at -20 - -15 ℃; for 0.5h;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195768-25-2
N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: pyridine / dmap / dichloromethane / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

4.2: 1.33 h / 0 - 20 °C

With pyridine; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester

: 1195768-25-2
N-{3-[2-(2-chloropyrimidin-4-yl)-acetyl]-2-fluoro-phenyl}-2,5-difluorobenzene-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / nickel / tetrahydrofuran; methanol; water / 70 °C

2.1: pyridine / dmap / dichloromethane / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

3.2: 1.33 h / 0 - 20 °C

With pyridine; hydrazine hydrate; lithium hexamethyldisilazane; dmap; nickel; In tetrahydrofuran; methanol; dichloromethane; water;