Methyl bis(4-methoxyphenyl)acetate

Base Information

• Chemical Name: Methyl bis(4-methoxyphenyl)acetate
• CAS No.: 5359-41-1
• Molecular Formula: C17H18O4
• Molecular Weight: 286.328
• DSSTox Substance ID: DTXSID10968364
• Wikidata: Q82951136
• Mol file: 5359-41-1.mol

Synonyms:methyl bis(4-methoxyphenyl)acetate;5359-41-1;Methyl 4-methoxy-alpha-(4-methoxyphenyl)benzeneacetate;Benzeneacetic acid, 4-methoxy-alpha-(4-methoxyphenyl)-, methyl ester;methyl 2,2-bis(4-methoxyphenyl)acetate;Oprea1_519291;DTXSID10968364;STL321970;AKOS022113449

Chemical Property of Methyl bis(4-methoxyphenyl)acetate

Chemical Property:

• Vapor Pressure: 7.55E-07mmHg at 25°C
• Boiling Point: 407.4°Cat760mmHg
• Flash Point: 179°C
• Density: 1.126g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 286.12050905
• Heavy Atom Count: 21
• Complexity: 291

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)C(=O)OC

Technology Process of Methyl bis(4-methoxyphenyl)acetate

There total 7 articles about Methyl bis(4-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methanol (67-56-1) + Methoxychlor (72-43-5,105367-23-5) → methyl ester of 2,2-bis(4,4'-dimethoxyphenyl)ethanoic acid (5359-41-1)

Guidance literature:

With tetrabutylammonium perchlorate; C₅₄H₇₅CoN₃O₁₄⁽¹⁺⁾*ClO₄^(1-); N-ethyl-N,N-diisopropylamine; In acetonitrile; at 30 ℃; Electrochemical reaction;

DOI:10.1246/bcsj.20210316

Reference yield: 54.0%

dimethoxycarbene (40480-72-6) + bis(4-methoxyphenyl)thione (958-80-5) → methyl ester of 2,2-bis(4,4'-dimethoxyphenyl)ethanoic acid (5359-41-1)

Guidance literature:

DOI:10.1002/poc.857

Reference yield: 47.0%

methyl 2-chloro-2-methoxyacetate (13157-96-5) + methoxybenzene (100-66-3) → methyl ester of 2,2-bis(4,4'-dimethoxyphenyl)ethanoic acid (5359-41-1) + Methyl α-methoxy-o-methoxyphenylacetate (138197-78-1)

Guidance literature:

With tin(IV) chloride; at 0 ℃; for 1h;

DOI:10.1016/0040-4039(91)80781-Z

upstream raw materials:

methanol

2,2-bis-(4-methoxyphenyl)acetic acid

2,2-bis (4-hydroxyphenyl)acetic acid

dimethyl sulfate

Downstream raw materials:

3-(4,4'-dimethoxy-benzhydryl)-pentan-3-ol

diethylstilbestrol

Diethylstilbestrol dimethyl ether

2-ethyl-1,1-bis-(4-methoxy-phenyl)-but-1-ene