(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Base Information

Chemical Name:(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one
CAS No.:132575-63-4
Molecular Formula:C₉H₁₄O₄
Molecular Weight:186.208
Hs Code.:

Synonyms:(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Suppliers and Price of (3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ACHEMBLOCK
(3aR,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyldihydro-3ah-cyclopenta[d][1,3]dioxol-4(5H)-one 95%
5G
$ 7450.00

ACHEMBLOCK
(3aR,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyldihydro-3ah-cyclopenta[d][1,3]dioxol-4(5H)-one 95%
1G
$ 2650.00

Total 6 raw suppliers

Chemical Property of (3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3aR,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyldihydro-3ah-cyclopenta[d][1,3]dioxol-4(5H)-one 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

There total 9 articles about (3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 115509-13-2
(3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one

: 132575-63-4
(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Guidance literature:: With benzophenone; for 1h; Irradiation;
DOI:10.1016/0968-0896(96)00090-9

Reference yield:

: 141436-58-0,126113-84-6
(-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol

: 132575-63-4
(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate / dichloromethane / 0.67 h / 0 - 20 °C / Inert atmosphere

2.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere; Reflux

3.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C / Inert atmosphere

4.1: manganese(IV) oxide / dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: benzophenone / 1 h / Inert atmosphere; Irradiation

With Grubbs catalyst first generation; manganese(IV) oxide; sodium periodate; benzophenone; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/acs.orglett.8b04003

Reference yield:

: 67814-68-0,70266-87-4,76249-50-8,76249-51-9,93451-15-1,4099-88-1
2,3-O-isopropylidene-D-ribofuranose

: 132575-63-4
(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 16 h / -78 - 0 °C / Inert atmosphere

2.1: sodium periodate / dichloromethane / 0.67 h / 0 - 20 °C / Inert atmosphere

3.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere; Reflux

4.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: manganese(IV) oxide / dichloromethane / 24 h / 20 °C / Inert atmosphere

6.1: benzophenone / 1 h / Inert atmosphere; Irradiation

With Grubbs catalyst first generation; manganese(IV) oxide; sodium periodate; benzophenone; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/acs.orglett.8b04003