(R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

Base Information

Chemical Name:(R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one
CAS No.:136779-90-3
Molecular Formula:C₂₄H₃₇NO₂Si
Molecular Weight:399.649
Hs Code.:

Synonyms:(R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

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Technology Process of (R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

There total 8 articles about (R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20585-34-6
(S)-cyclohexylmandelic acid

: 136722-11-7,136779-90-3
(S)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; tetrahydrofuran / 1.) 25 deg C, 3.5 h, 2.) reflux, 3 h

2: imidazole / dimethylformamide / 85 °C

3: 1.) 1,1,1,3,3,3-hexamethyldisilazane (HMDS), n-BuLi / 1.) THF, hexane, 45 min, 2.) THF, hexane, from -78 deg C to RT, 3 h

4: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 1 h

With 1H-imidazole; n-butyllithium; copper diacetate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00114a016

Reference yield:

: 28192-98-5,136722-57-1,136779-88-9
(S)-1-cyclohexyl-1-hydroxy-1-phenyl-2-propanone

: 136722-11-7,136779-90-3
(S)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 85 °C

2: 1.) 1,1,1,3,3,3-hexamethyldisilazane (HMDS), n-BuLi / 1.) THF, hexane, 45 min, 2.) THF, hexane, from -78 deg C to RT, 3 h

3: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 1 h

With 1H-imidazole; n-butyllithium; copper diacetate; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jm00114a016

Reference yield:

: 136779-88-9
(R)-1-cyclohexyl-1-hydroxy-1-phenyl-2-propanone

: 136779-90-3
(R)-1-cyclohexyl-7-(dimethylamino)-1-phenyl-1-(trimethylsiloxy)-5-heptyn-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 18.0 g / imidazole / dimethylformamide / 85 °C

2: 1.) 1,1,1,3,3,3-hexamethyldisilazane (HMDS), n-BuLi / 1.) THF, hexane, 45 min, 2.) THF, hexane, from -78 deg C to RT, 3 h

3: 1.) Cu(OAc)2 / 1.) H₂O, dioxane, 60 deg C, 1 h, 2.) H₂O, dioxane, 90 deg C, 1 h

With 1H-imidazole; n-butyllithium; copper diacetate; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jm00114a016