Technology Process of (+/-)-(1β,2α,3β,4α,5α)-1-(6-amino-9H-purin-9-yl)-4,5-(dimethylmethylenedioxy)-2-<(1-imidazolylthiocarbonyl)oxy>-3-<(phenylmethoxy)methyl>cyclopentane
There total 11 articles about (+/-)-(1β,2α,3β,4α,5α)-1-(6-amino-9H-purin-9-yl)-4,5-(dimethylmethylenedioxy)-2-<(1-imidazolylthiocarbonyl)oxy>-3-<(phenylmethoxy)methyl>cyclopentane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: O2, thiourea, sodium acetate, Rose bengal / methanol / 9 h / -5 °C / Irradiation
2: 62 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 48 h / Ambient temperature
3: 100 percent / sodium azide / dimethylformamide / 12 h / 110 °C
4: 92 percent / 75percent aq. HClO4 / acetone / 1 h / Ambient temperature
5: 88 percent / H2 / Lindlar catalyst / methanol / 12 h / 760 Torr
6: 68 percent / pyridine, N-methylpyrrolidinone / 12 h / 180 °C
7: 2.) p-toluenesulfonic acid / 1.) reflux, 12 h, 2.) toluene, RT, 1 h
8: NH3 / methanol / 48 h / 60 °C
9: 100 percent / dimethylformamide / 2 h / 70 °C
With
pyridine; 1-methyl-pyrrolidin-2-one; sodium azide; perchloric acid; ammonia; hydrogen; oxygen; sodium acetate; rose bengal; toluene-4-sulfonic acid; thiourea; 3-chloro-benzenecarboperoxoic acid;
Lindlar's catalyst;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00358a023
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 62 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: 100 percent / sodium azide / dimethylformamide / 12 h / 110 °C
3: 92 percent / 75percent aq. HClO4 / acetone / 1 h / Ambient temperature
4: 88 percent / H2 / Lindlar catalyst / methanol / 12 h / 760 Torr
5: 68 percent / pyridine, N-methylpyrrolidinone / 12 h / 180 °C
6: 2.) p-toluenesulfonic acid / 1.) reflux, 12 h, 2.) toluene, RT, 1 h
7: NH3 / methanol / 48 h / 60 °C
8: 100 percent / dimethylformamide / 2 h / 70 °C
With
pyridine; 1-methyl-pyrrolidin-2-one; sodium azide; perchloric acid; ammonia; hydrogen; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
Lindlar's catalyst;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00358a023