4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Base Information

Chemical Name:4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile
CAS No.:1616435-08-5
Molecular Formula:C₂₃H₂₄ClF₃N₆
Molecular Weight:476.932
Hs Code.:

Synonyms:4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Chemical Property of 4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Technology Process of 4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

There total 16 articles about 4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2730-67-8
N-methyl-N-(2,2,2-trifluoroethyl)amine

: 1616434-31-1
2-bromo-4-(5-chloropyridin-3-yl)-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

: 1616435-08-5
4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: With cesium fluoride; In dimethyl sulfoxide; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1616435-08-5
4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -20 - 20 °C

2: iron; water / ethanol / 10 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 15 h / 45 °C

5: acetic anhydride / 3 h / 90 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Sealed tube

7: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; zinc; palladium diacetate; sulfuric acid / N,N-dimethyl acetamide / 3.5 h / 100 °C / Inert atmosphere

8: N-Bromosuccinimide / chloroform / 1 h / Reflux

9: cesium fluoride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; palladium diacetate; acetic anhydride; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; dimethyl sulfoxide;

Reference yield:

: 1313726-52-1
tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate

: 1616435-08-5
4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: iron; water / ethanol / 10 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 15 h / 45 °C

4: acetic anhydride / 3 h / 90 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Sealed tube

6: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; zinc; palladium diacetate; sulfuric acid / N,N-dimethyl acetamide / 3.5 h / 100 °C / Inert atmosphere

7: N-Bromosuccinimide / chloroform / 1 h / Reflux

8: cesium fluoride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; palladium diacetate; acetic anhydride; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride; zinc; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; dimethyl sulfoxide;