4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

Base Information

Chemical Name:4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide
CAS No.:1616435-09-6
Molecular Formula:C₂₃H₂₇ClF₃N₇O
Molecular Weight:509.962
Hs Code.:

4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

Synonyms:4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

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Chemical Property of 4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

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Technology Process of 4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

There total 17 articles about 4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616435-08-5
4-(5-chloropyridin-3-yl)-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

: 1616435-09-6
4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

Guidance literature:: With hydroxylamine; In ethanol; water; at 20 ℃; for 3h;

Reference yield:

: 1313726-52-1
tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate

: 1616435-09-6
4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

Guidance literature:: Multi-step reaction with 9 steps

1: iron; water / ethanol / 10 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 15 h / 45 °C

4: acetic anhydride / 3 h / 90 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Sealed tube

6: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; zinc; palladium diacetate; sulfuric acid / N,N-dimethyl acetamide / 3.5 h / 100 °C / Inert atmosphere

7: N-Bromosuccinimide / chloroform / 1 h / Reflux

8: cesium fluoride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere; Sealed tube

9: hydroxylamine / water; ethanol / 3 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; hydroxylamine; palladium diacetate; acetic anhydride; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride; zinc; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; dimethyl sulfoxide;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1616435-09-6
4-(5-chloropyridin-3-yl)-N-hydroxy-2-(methyl(2,2,2-trifluoroethyl)amino)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carboximidamide

Guidance literature:: Multi-step reaction with 10 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -20 - 20 °C

2: iron; water / ethanol / 10 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 15 h / 45 °C

5: acetic anhydride / 3 h / 90 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Sealed tube

7: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; zinc; palladium diacetate; sulfuric acid / N,N-dimethyl acetamide / 3.5 h / 100 °C / Inert atmosphere

8: N-Bromosuccinimide / chloroform / 1 h / Reflux

9: cesium fluoride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere; Sealed tube

10: hydroxylamine / water; ethanol / 3 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; hydroxylamine; palladium diacetate; acetic anhydride; sodium tris(acetoxy)borohydride; iron; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; dimethyl sulfoxide;