tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate
CAS No.:1400808-32-3
Molecular Formula:C₃₀H₂₉FN₄O₂S₂
Molecular Weight:560.716
Hs Code.:

Synonyms:tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

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Chemical Property of tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

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Technology Process of tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

There total 6 articles about tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1400808-31-2
C₁₆H₁₇FN₄O₂S₂

: 100-44-7
benzyl chloride

: 1400808-32-3
tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

Guidance literature:: With water; In ethanol; dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1400808-32-3
tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; tetrahydrofuran / 1.33 h / Cooling with ice

2.1: dmap / tetrahydrofuran; methanol / 7 h / 20 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 0 °C / Cooling with ice

4.1: sodium hydrogencarbonate; sodium dithionite / 1,2-dimethoxyethane; water / 12 h / 40 °C / Inert atmosphere

5.1: sodium hydroxide / ethanol; water / 0.25 h / 50 °C / Sealed tube

5.2: 43 h / 20 - 80 °C / Inert atmosphere

6.1: ethanol; water; dimethyl sulfoxide / 20 °C / Cooling with ice

With dmap; sodium dithionite; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1400808-30-1
tert-butyl 2-amino-3-cyano-5-fluoro-1H-indol-7-yl(methyl)carbamate

: 1400808-32-3
tert-butyl 2,4-bis(benzylthio)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 0.25 h / 50 °C / Sealed tube

1.2: 43 h / 20 - 80 °C / Inert atmosphere

2.1: ethanol; water; dimethyl sulfoxide / 20 °C / Cooling with ice

With sodium hydroxide; In ethanol; water; dimethyl sulfoxide;