tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate
CAS No.:1581683-76-2
Molecular Formula:C₂₈H₂₇FN₆O₃S₂
Molecular Weight:578.691
Hs Code.:

Synonyms:tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

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Chemical Property of tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

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Technology Process of tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

There total 8 articles about tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1400808-33-4
tert-butyl N-[2,4-bis(benzylsulfonyl)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl]-N-methylcarbamate

: 100-53-8
phenylmethanethiol

: 4874-33-3
2-methylthio-5-hydroxypyrimidine

: 1581683-76-2
tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

Guidance literature:: tert-butyl N-[2,4-bis(benzylsulfonyl)-6-fluoro-9H-pyrimido[4,5-b]indol-8-yl]-N-methylcarbamate; phenylmethanethiol; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 0 - 40 ℃; for 1h;

2-methylthio-5-hydroxypyrimidine; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 2h;

Reference yield:

: 1400808-31-2
C₁₆H₁₇FN₄O₂S₂

: 1581683-76-2
tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / ethanol; dimethyl sulfoxide / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 20 °C / Cooling with ice

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 0 - 40 °C

3.2: 2 h / 110 °C

With water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1400808-14-1
tert-butyl 3,5-difluoro-2-nitrophenyl(methyl)carbamate

: 1581683-76-2
tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: sodium hydrogencarbonate; sodium dithionite / N,N-dimethyl-formamide; water / 12 h / 40 °C / Inert atmosphere

3.1: sodium hydroxide / ethanol / 0.25 h / 50 °C / Sealed tube

3.2: 43 h / 20 - 80 °C / Inert atmosphere

4.1: water / ethanol; dimethyl sulfoxide / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 20 °C / Cooling with ice

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 0 - 40 °C

6.2: 2 h / 110 °C

With sodium dithionite; water; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;