diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

Base Information

Chemical Name:diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate
CAS No.:1581683-86-4
Molecular Formula:C₃₈H₃₅FN₆O₁₀
Molecular Weight:754.729
Hs Code.:

Synonyms:diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

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Chemical Property of diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

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Technology Process of diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

There total 11 articles about diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1581683-77-3
tert-butyl (4-(benzylsulfonyl)-6-fluoro-2-((2-(methylsulfonyl)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

: 1581683-85-3
ethyl 2-(3-cyano-5-hydroxyphenoxy)acetate

: 1581683-86-4
diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 1h;

Reference yield:

: 1581683-76-2
tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

: 1581683-86-4
diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 40 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 19179-36-3
3,5-dihydroxycyanobenzene

: 1581683-86-4
diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

With potassium carbonate; In 1-methyl-pyrrolidin-2-one;