(2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
• CAS No.: 130159-77-2
• Molecular Formula: C₂₄H₂₉NO₈S
• Molecular Weight: 491.562
• Mol file: 130159-77-2.mol

Synonyms:(2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Chemical Property of (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

There total 16 articles about (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + (2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester (135075-71-7) → (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester (130159-77-2)

Guidance literature:

With sulfuric acid; In chloroform; for 10h; Heating;

DOI:10.1021/jo00014a028

Reference yield: 95.0%

methanol (67-56-1) + (2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester (135075-72-8) → (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester (130159-77-2)

Guidance literature:

With sulfuric acid; In chloroform; for 15h; Heating;

DOI:10.1021/jo00014a028

Reference yield: 89.0%

methanol (67-56-1) + (2R,3R,4R,5S)-5-Phenyl-3-((3R,7aS)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester (130179-66-7) → (2R,3R,4R,5S)-3-Dimethoxymethyl-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester (130159-77-2)

Guidance literature:

With sulfuric acid; silica gel; for 20h; Heating;

DOI:10.1246/bcsj.63.2857

upstream raw materials:

methanol

(2R,3R,4R,5S)-5-Phenyl-3-((3R,7aS)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

(2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

(2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester