6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

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Chemical Name:6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone
CAS No.:403483-52-3
Molecular Formula:C₂₇H₄₀O₃Si
Molecular Weight:440.698
Hs Code.:

Synonyms:6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

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Chemical Property of 6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

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Technology Process of 6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

There total 10 articles about 6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13395-73-8
4,4,6-trimethylcyclohex-2-en-1-one

: 403483-51-2
(2E)-1-iodo-3-(dimethylphenylsilyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]pentene

: 403483-52-3
6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide;
DOI:10.1016/S0040-4039(01)02026-3 DOI:10.1021/jo026702j

Reference yield: 87.0%

: 6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4-dimethyl-cyclohex-2-enone

: 74-88-4
methyl iodide

: 403483-52-3
6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

Guidance literature:: DOI:10.1016/S0040-4039(01)02026-3

Reference yield:

: 51442-80-9
5-(tetrahydro-2H-pyran-2-yloxy)-2-pentyn-1-ol

: 403483-52-3
6-[(E)-3-(Dimethyl-phenyl-silanyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl]-4,4,6-trimethyl-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / CuCN / tetrahydrofuran / -78 - -20 °C

2: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

3: NaI / acetone / 0.25 h / 45 °C

4: 90 percent / LDA; DMPU

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo026702j