3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

Base Information

Chemical Name:3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid
CAS No.:1455090-05-7
Molecular Formula:C₂₀H₁₅F₃N₂O₅
Molecular Weight:420.345
Hs Code.:

Synonyms:3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

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Chemical Property of 3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

Chemical Property:

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Technology Process of 3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

There total 8 articles about 3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-37-7
4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carboxylic acid methyl ester

: 107-95-9
3-amino propanoic acid

: 1455090-05-7
3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455090-05-7
3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

4: copper(l) iodide / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

5: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; copper(l) iodide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1455091-06-1
2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

: 1455090-05-7
3-[(4-hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

3: copper(l) iodide / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; copper(l) iodide; sodium methylate; dibenzoyl peroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;