(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

Base Information

Chemical Name:(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate
CAS No.:1372526-40-3
Molecular Formula:C₂₈H₃₇ClN₂O₄
Molecular Weight:501.066
Hs Code.:

Synonyms:(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

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Technology Process of (S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

There total 6 articles about (S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1118-02-1
trimethylsilyl isocyanate

: 1372526-38-9
(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

: 1372526-40-3
(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm201608g

Reference yield:

: 1372526-57-2
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

: 1372526-40-3
(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

2.2: 4 h / 20 °C

3.1: dmap / dichloromethane / 4 h / 20 °C

With dmap; trimethylaluminum; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-40-3
(S)-1-(4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)octan-2-yl carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

3.2: 4 h / 20 °C

4.1: dmap / dichloromethane / 4 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; trimethylaluminum; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction;
DOI:10.1021/jm201608g