tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate
CAS No.:1372526-57-2
Molecular Formula:C₂₄H₂₈ClNO₄
Molecular Weight:429.944
Hs Code.:

Synonyms:tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1372526-57-2
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 3h;
DOI:10.1021/jm201608g

Reference yield: 93.0%

: 637-87-6
1-Chloro-4-iodobenzene

: carboxy MIDA boronate

: 3-(N-Boc-piperidin-4-ylmethoxy)phenylboronic acid

: 1372526-57-2
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In toluene; at 80 ℃; for 20h; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.202010211

Reference yield:

: 32363-45-4
(4-chlorophenyl)(3-methoxyphenyl)methanone

: 1372526-57-2
tert-butyl 4-{[3-(4-chlorobenzoyl)phenoxy]methyl}-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / water / 36 h / 125 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

With di-isopropyl azodicarboxylate; hydrogen bromide; acetic acid; triphenylphosphine; In tetrahydrofuran; water; 2: Mitsunobu reaction;
DOI:10.1021/jm201608g