(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

Base Information

Chemical Name:(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone
CAS No.:1372526-38-9
Molecular Formula:C₂₇H₃₆ClNO₃
Molecular Weight:458.041
Hs Code.:

Synonyms:(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

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Chemical Property of (S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

Chemical Property:

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Technology Process of (S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

There total 6 articles about (S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1372526-58-3
(4-chlorophenyl)(3-(piperidin-4-ylmethoxy)phenyl)methanone

: 2984-50-1,50418-68-3,77495-66-0,77549-73-6
(2S)-2-hexyloxirane

: 1372526-38-9
(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

Guidance literature:: (4-chlorophenyl)(3-(piperidin-4-ylmethoxy)phenyl)methanone; With trimethylaluminum; In dichloromethane; at 0 ℃; for 0.25h;

(2S)-2-hexyloxirane; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-38-9
(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

3.2: 4 h / 20 °C

With di-isopropyl azodicarboxylate; trimethylaluminum; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction;
DOI:10.1021/jm201608g

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 1372526-38-9
(S)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C

1.2: 3.5 h / -78 - 0 °C

2.1: hydrogen bromide; acetic acid / water / 36 h / 125 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

5.2: 4 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen bromide; trimethylaluminum; isopropylmagnesium chloride; acetic acid; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 3.1: Mitsunobu reaction;
DOI:10.1021/jm201608g