(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

Base Information

Chemical Name:(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol
CAS No.:329359-45-7
Molecular Formula:C₄₁H₆₄O₁₀Si
Molecular Weight:745.039
Hs Code.:

(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

Synonyms:(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

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Chemical Property of (2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

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Technology Process of (2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

There total 14 articles about (2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329359-61-7
(S)-1-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-one

: (2S,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

: 329359-45-7
(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; Title compound not separated from byproducts;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C

Reference yield:

: (2S,4S)-5-[2-((2S,4R)-5-Benzyloxy-2,4-dihydroxy-pentyl)-[1,3]dithian-2-yl]-4-methoxy-pentane-1,2-diol

: 329359-45-7
(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: Hg(ClO₄)2; CaCO₃ / acetonitrile; H₂O

2.1: HClO₄ / CH₂Cl₂; acetonitrile

3.1: 87 percent / Et₃N / CH₂Cl₂

4.1: 99 percent / imidazole / dimethylformamide

5.1: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

6.1: 90 percent / I₂; PPh₃; imidazole / benzene

7.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

7.2: 95 percent / tetrahydrofuran / -78 - 0 °C

8.1: 71 percent / Hg(ClO₄)2; CaCO₃ / methanol; H₂O / 0 °C

9.1: NaBH₄ / methanol; CH₂Cl₂

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; perchloric acid; mercury(II) perchlorate; iodine; tert.-butyl lithium; diisobutylaluminium hydride; triethylamine; triphenylphosphine; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C

Reference yield:

: 201275-41-4
(S)-4-((S)-3-{2-[(2S,4R)-5-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-pentyl]-[1,3]dithian-2-yl}-2-methoxy-propyl)-2,2-dimethyl-[1,3]dioxolane

: 329359-45-7
(2R,3R)-1-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 85 percent / HCl / methanol

2.1: Hg(ClO₄)2; CaCO₃ / acetonitrile; H₂O

3.1: HClO₄ / CH₂Cl₂; acetonitrile

4.1: 87 percent / Et₃N / CH₂Cl₂

5.1: 99 percent / imidazole / dimethylformamide

6.1: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

7.1: 90 percent / I₂; PPh₃; imidazole / benzene

8.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

8.2: 95 percent / tetrahydrofuran / -78 - 0 °C

9.1: 71 percent / Hg(ClO₄)2; CaCO₃ / methanol; H₂O / 0 °C

10.1: NaBH₄ / methanol; CH₂Cl₂

With 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; perchloric acid; mercury(II) perchlorate; iodine; tert.-butyl lithium; diisobutylaluminium hydride; triethylamine; triphenylphosphine; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C