isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

Base Information

Chemical Name:isopropyl 2-(benzyloxy)-8-hydroxyoctanoate
CAS No.:1358536-66-9
Molecular Formula:C₁₈H₂₈O₄
Molecular Weight:308.418
Hs Code.:

Synonyms:isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

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Chemical Property of isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

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Technology Process of isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

There total 6 articles about isopropyl 2-(benzyloxy)-8-hydroxyoctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1358536-64-7
isopropyl 2-(benzyloxy)-8-(tert-butyldimethylsilyloxy)octanoate

: 1358536-66-9
isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.12.025

Reference yield:

: 103202-59-1
6-(tert-butyldimethylsilyl)oxyhexan-1-ol

: 1358536-66-9
isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 3.25 h / 20 °C / Inert atmosphere

2.1: potassium isopropoxide / diethyl ether; isopropyl alcohol / 0.17 h / 0 °C / Inert atmosphere

2.2: 1.67 h / 0 °C / Inert atmosphere

3.1: sodium cyanoborohydride / isopropyl alcohol / 43 h / 70 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium iodide; silver(l) oxide / dichloromethane / 9 h / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium isopropoxide; sodium cyanoborohydride; Dess-Martin periodane; potassium iodide; silver(l) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; 2.2: Darzens condensation;
DOI:10.1016/j.bmcl.2011.12.025

Reference yield:

: 1358536-50-1
C₁₇H₃₃ClO₄Si

: 1358536-66-9
isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride / isopropyl alcohol / 43 h / 70 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium iodide; silver(l) oxide / dichloromethane / 9 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium cyanoborohydride; potassium iodide; silver(l) oxide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.12.025